DataNucleus supports persisting/retrieving objects to/from OOXML documents (using the datanucleus-excel plugin) which makes use of the Apache POI project. Simply specify your "connectionURL" as follows
replacing "myfile.xlsx" with your filename, which can be absolute or relative. This connects to a file on your local machine. You then create your PMF/EMF as normal and use JDO/JPA as normal.
The jars required to use DataNucleus OOXML persistence are datanucleus-core, datanucleus-api-jdo/datanucleus-api-jpa, datanucleus-excel and apache-poi
Things to bear in mind with OOXML usage :-